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Just one drink can change the brain in the long term! Development of "Alcohol Addiction"

Posting time:2023-01-31 09:27:58

Just one drink can change the brain in the long term! Development of "Alcohol Addiction"

Article Source: Swagpp Mays Medicine

Just one drink can change the brain long-term! PNAS: A single intoxication can change neurons, or develop into "alcohol addiction"

People who never drink may have difficulty understanding alcohol lovers, "beer is bitter, liquor is spicy", what's so good about alcohol ? In fact, drinking has been an essential part of people's lives for thousands of years. In addition to using alcohol to relieve anxiety and sustenance feelings, alcohol is also a "lubricant" for social interaction, and has even been given the role of communicating feelings and solving problems. The harm of alcohol is self-evident, and the most well-known one is "addiction", so alcohol is also the most widely used addictive substance in the world. According to incomplete statistics, only 5% of adults in the world will not drink alcohol in their lifetime, and except for this part of the complete abstinence, other drinkers of any degree are counted as potential groups of alcohol addiction. It is well known that as the amount and frequency of alcohol consumption increases, the risk of alcohol addiction and health damage naturally increases. But can't you just take a sip? Does drinking alcohol just once lead to addiction? That's right! Single-dose ethanol intoxication causes acute and lasting neuronal changes in the brain by German researchers published in the journal PNAS shows that even a single drink of alcohol may permanently alter the shape of neurons in the brain, especially affecting the hippocampus Synapse structure and mitochondrial dynamics, which in turn induce alcohol addiction! In other words, people who have never drunk alcohol should never touch the "Pandora's Box" of alcohol! You think it's just a "sweet spot" to try once, but it's likely to plant the "sinful seeds" of long-term alcoholism. Just a single administration of 50 mM ethanol (the amount that causes acute alcohol intoxication) in mice induces changes in the abundance levels of hippocampal synaptic proteins in the brain, and this The changes were more pronounced in young mice. Specifically, under the stimulation of ethanol, the researchers detected significant changes in 72 proteins in the mouse hippocampus, including malate dehydrogenase, monoamine oxidase A, GAP-43 and tyrosine protein kinase Fyn. Furthermore, ethanol decreased the synaptic abundance of the gamma-aminobutyric acid (GABA) reuptake transporters GAT4 and GABA transaminase and increased GABA signaling in the brain. Notably, acute ethanol exposure also affected ankyrin-G and MAP6, two proteins critical for maintaining spine stability. Collectively, a single episode of acute alcohol intoxication altered multiple proteins in the mouse brain, affecting synaptic transmission and plasticity, mitochondrial function, apoptosis, and neurodegenerative diseases. More seriously, alcohol damage was persistent in synaptic accumulation, meaning that the brain damage persisted even in mice with high levels of ethanol metabolism. In vivo immunofluorescence detection of alcohol-dependent synapsin dynamics Not only that, the researchers also observed a significant increase in mitochondrial mobility in the thalamus of mice after drinking alcohol: within 1 h of acute alcohol intoxication, mitochondrial mobility was significantly increased in the brain , and peaked at 3h; and this effect of increasing mitochondrial fluidity was maintained for about 4h, and did not return to the baseline level until one day later. This higher mitochondrial mobility interferes with the normal movement of mitochondria and prevents optimal energy transfer. The specific performance is that the precise behavior, false alarm rate, efficiency and performance of the mice decreased significantly. That is to say, after the mice were drunk, they walked crookedly, their response to emergencies became very slow, and the efficiency of doing things and The degree of completion will be greatly reduced, and this situation lasted for at least 48h. The effects of ethanol on mitochondrial motility further alter the plasticity of brain neurons. The morphological remodeling of these neurons is the basis of learning and memory, and is also a crucial part of the process of alcohol addiction. This also explains why a single "drunk" can lead to alcoholism and even addiction. Mitochondrial motility is required to mediate the positive rewarding properties of ethanol in dopaminergic neurons, says study leader Professor Henrike Scholz. The cellular processes leading to this complex rewarding behavior are highly similar even across species. Sex, so the mechanism of "alcoholism and addiction" can be analogized to humans. Thus, personally, "early first" intoxication is a key risk factor for alcoholism and addiction later in life. Taken together, animal experiments demonstrate that a single acute ethanol intoxication leads to short- and long-term changes in synaptic protein and mitochondrial dynamics, further inducing neuronal changes associated with alcohol addiction, and this effect is more pronounced in early life. . For humans, getting drunk for the first time early in life can change your brain or put you on the "road of no return" to alcoholism! Therefore, people who "do not drink a drop of alcohol" must adhere to this good habit! Alcohol damages the brain is not just talk, you think that "just one" attempt is also likely to plant "the seeds of sin". The Mid-Autumn Festival is approaching. If someone insists on letting you drink it, you can only take out the "wine-stopping artifact" cephalosporin. Reference: Johannes Knabbe et al, Single-dose ethanol intoxication causes acute and lasting neuronal changes in the brain, Proceedings of the National Academy of Sciences (2022). DOI: 10.1073/pnas.2122477119. Written | Edited by Swagpp | Swagpp

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