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Type O blood wins! Study of 600,000 people finds that blood type can predict stroke risk before age 60

Posting time:2022-10-06 01:35:39

Type O blood wins! Study of 600,000 people finds that blood type can predict stroke risk before age 60

Article source: Bio Valley Mays Medicine

O blood type wins! A study of 600,000 people found that blood type can predict the risk of stroke before the age of 60, and blood type O has the lowest risk! The highest is...

Stroke, also known as "stroke", it is reported that a Chinese person dies from a stroke every 16 seconds on average. A stroke is a specific event that damages the brain or causes brain tissue to die. The most common type of stroke is ischemic stroke. An ischemic stroke occurs when something, such as a blood clot, blocks the blood supply to the brain. Without an adequate blood supply, the brain cannot get the oxygen it needs, and brain cells die from lack of oxygen. The brain controls the rest of the body, so damage to it can have long-term consequences. Thus, identifying risk factors for stroke can contribute to awareness and hopefully prevent stroke. A person's blood type may be associated with their risk of early stroke, with type A having the highest risk of stroke before age 60, according to a new meta-analysis led by researchers at the University of Maryland School of Medicine (UMSOM). People with blood type O have the lowest risk of stroke. The findings were published in the journal Neurology. The meta-analysis included all available data from genetic studies, with a focus on ischemic stroke caused by blockage of blood flow to the brain, which occurs in young adults under the age of 60. "The number of early strokes is on the rise," said neurologist Steven J. Kittner of the University of Maryland Medical Center. "These individuals are more likely to die from life-threatening events, and survivors can face decades of disability. Nonetheless, the number of early strokes is on the rise. There are very few studies on the cause." He and his colleagues conducted a meta-analysis of 48 studies on genetic and ischemic stroke, including 16,730 stroke cases and 599,237 healthy controls who had never experienced a stroke. They then looked at all the collected chromosomes to identify genetic variants associated with stroke and found a link between early-onset stroke (occurring before age 60) and a region of the chromosome that determines whether blood types are A, AB, B and O blood types. For this study, researchers divided participants by blood type and compared them with stroke status: early stroke, late stroke, and no stroke. The results found: 1. Compared with people who had stroke or no stroke later in life, people with early stroke were more likely to have blood type A, and less likely to have blood type O; 2. Compared with the control group, people with early and late stroke People who have had a stroke are more likely to have blood type B. After adjusting for gender and other factors, the researchers found: 1. People with blood type A had an 18 percent higher risk of early stroke than people with different blood types; 2. People with blood type O had a lower risk of early stroke than people with other blood types 12%. "Our meta-analysis looked at people's genetic profiles and found an association between blood type and early-onset stroke risk," said study collaborator and principal investigator Braxton D. Mitchell. "The association between blood type and late-onset stroke was stronger than what we found. Early-onset stroke is much weaker." The researchers stress that the increased risk of stroke is very modest, and people with blood type A should not worry about early-onset stroke or have additional screening or medical testing based on this finding. In addition, the researchers added: "We still don't know why blood type A is associated with a higher risk, but it may be related to clotting factors such as platelets and vascular endothelial cells and other circulating proteins, all of which play a role in thrombosis. Previous studies have shown that people with blood type A have a slightly higher risk of developing blood clots in the legs, called deep vein thrombosis. We clearly need more follow-up studies to elucidate the mechanisms of increased stroke risk." Limitations: 1. The study mainly included participants of European ancestry. About 35% of the participants were of non-European ancestry. This means that more diverse follow-up is needed; 2. The study was also unable to determine the cause of this link between blood type and stroke, so further data collection could focus on causal factors rather than associations; 3. The sample size is limited , limiting the researchers' ability to look at unique subtypes and more detailed factors. In any case, this study tells you that many people are likely to experience a stroke, and the conclusion of this study should lead to changes in stroke risk factors. While people can't change their blood type, people can control for other stroke risk factors to help reduce risk. For example, high blood pressure, diabetes, high cholesterol levels, smoking, and obesity are all risk factors for stroke. People can take steps to modify these risk factors, such as following healthy dietary recommendations and exercising regularly, and staying in close contact with doctors and other medical professionals to push themselves toward a healthy lifestyle and address underlying health problems. Reference: https://n.neurology.org/content/early/2022/08/31/WNL.0000000000201006 Written | Edited by Cathy | Little Ears

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