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Does the more coffee you drink, the higher your risk of POAG? Check out the latest research

Posting time:2022-12-03 10:19:06

Does the more coffee you drink, the higher your risk of POAG? Check out the latest research

Editor's Note: Glaucoma is the leading cause of irreversible blindness worldwide, with more than 76 million people estimated to suffer from glaucoma. Notably, this number is expected to increase to about 112 million by 2040. Because there are no special symptoms in the early stage of glaucoma, it is easy to be ignored, thus delaying the early diagnosis and treatment. When the disease progresses to the advanced stage, it will be noticed by the patient, which has already caused irreversible vision loss. The biological basis of the disease is not fully understood, ocular hypertension (IOP) is the only known modifiable risk factor for glaucoma, and existing interventions all work by reducing IOP. Studies have shown that coffee, a widely consumed non-alcoholic beverage, can affect intraocular pressure. However, few studies have assessed the association between coffee intake and glaucoma, and its causality remains unclear. In a new study, researchers using a two-sample Mendelian randomization method found that higher coffee intake was associated with a higher risk of POAG. Using two-sample Mendelian randomization, the researchers obtained data from a genome-wide association study of 121,824 participants and identified genetic variants associated with coffee intake. Data on coffee intake from the MRC-IEU UK Biobank were applied and POAG data were collected from multiple meta-analyses, including POAG individuals (16,677) and controls (199,580). Three sets of variables were used to assess the causal relationship between coffee intake and POAG risk, and the results were analyzed as follows: Genes predicted higher coffee intake phenotype 1 (cup/day) was significantly associated with higher risk of POAG ( Odds ratio [OR], 1.241; 95% confidence interval [CI], 1.041-1.480; P=0.016). Figure 1. Mendelian randomization (MR) scatter plot of association between coffee intake phenotype 1 (cups/day) and risk of POAG MBE = pattern-based estimate; MR = Mendelian randomization; POAG = primary Open-angle glaucoma; PRESSO=Pleiotropy RESidual Sum and outliers; SNP=Single nucleotide polymorphism gene predicts higher coffee intake phenotype 2 (high vs none/low) significantly associated with higher risk of POAG correlated (OR, 1.155; 95% CI, 1.038-1.284; P=0.008). Figure 2. Mendelian daily scatterplot of the association between coffee intake phenotype 2 (high vs none/low) and risk of primary POAG M = pattern-based low estimate; MR = Mendelian daily; POAG = Primary open-angle glaucoma; SNP = single nucleotide polymorphism In addition, from a genome-wide association study of genetically predicted MRC-IEU UK Biobank Open, higher coffee intake was significantly associated with a higher risk of POAG ( OR, 1.727; 95% CI, 1.230-2.425; P=0.002). Figure 3. Mendelian random scatter plot of the association between coffee intake and POAG risk from the IEU UK Biobank MBE = pattern-based estimation; MR = Mendelian randomization; POAG = primary open-angle glaucoma; PRESSO = Pleiotropy RESidual Sum and Outliers; SNP=Single Nucleotide Polymorphism Conclusions These findings provide genetic evidence that higher coffee intake is associated with higher risk of POAG. Given that coffee is widely consumed, the findings provide new insights into potential strategies for the prevention and management of POAG. Reference: Li, Xi & Cheng, Shiming & Cheng, Jingdan & Wang, Mengting & Zhong, Yiming & Yong, yu. (2022). Habitual Coffee Consumption Increases Risk of Primary Open-Angle Glaucoma: A Mendelian Randomization Study. Ophthalmology. 129. 10.1016/j.ophtha.2022.04.027. Subscription number search "International Ophthalmology News" or "iophthal" to view more exciting content (Source: "International Eye News" editorial department) Copyright statement Copyright belongs to "International Eye News" News" all. Personal forwarding and sharing are welcome. If any other media or website needs to reprint or quote the copyrighted content of this website, it must obtain the consent of this website and indicate at the top of the article "Reprinted from "International Ophthalmology News""

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